substrate proteins Archives - Projects, Thesis, Dissertation, Project Reports

Allostery in GroEL: Its Role in the Refolding of Protein Substrates

The Escherichia coli chaperonin GroEL assists in the re-folding of misfolded substrate proteins (SPs). In response to the binding of ATP, GroEL undergoes large, allosteric structural transitions, resulting in an expansion of its central cavity and a capping of the cavity by

Allostery and GroEL: Exploring the Tenets of Nested Cooperativity

Despite a wealth of structural and biochemical studies on the functional cycle of the E. coli chaperonins GroEL and GroES, no model proposed to date accounts for all the effects seen experimentally by the various allosteric ligands: ATP, ADP, SP, GroES, and

substrate proteins

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