Glucose and oxygen supply to the brain is crucial for its proper function and when it’s restricted as during a stroke, neurons and glial cells rapidly become necrotic resulting in structural damage as well as functional impairment and even death. Up to
The pancreatic islets are collections of endocrine cells, spread through the pancreas. In adult islets, endocrine cells are tightly related to capillary endothelial cells and get a high blood perfusion. Transplanted pancreatic islets, on the contrary, have a vascular disturbance, manifested as
Angiogenesis, de novo formation of blood vessels from the pre-existing vasculature, is crucial in embryo development, and in processes in the adult such as wound healing and ovulation. Angiogenesis is also involved in pathological conditions such as cancer and chronic inflammatory diseases,