The supraspinatus tendon is an important structure of the rotator cuff. Subacromial impingement is a common reason for shoulder pain. Despite extensive scientific work in this field, the cause of impingement syndrome is still not fully understood. The general aim of the present thesis was to generate new knowledge with respect to pathogenesis and treatment of impingement syndrome. A combination of animal and clinical studies were performed. Different methods were used such as histology, immunohistochemistry, development and assessment of a novel measuring device and clinical and radiological assessment.Thirty rats were injected with triamcinolone or saline into the subacromial bursa. After five corticosteroid injections, we found focal inflammation, degradation and fragmentation of collagen bundles in the supraspinatus tendon…
Contents
INTRODUCTION
• Human shoulder anatomy
• Impingement – clinical background
• Pathogenesis of the impingement syndrome
– Extrinsic
– Intrinsic
– Calcifications
• Treatment
– Non-operative treatment
– Corticosteroids
– Operative treatment
• Experimental background
– Animal model for impingement
– Carrageenan-induced bursitis
– Markers for tendon pathology
PURPOSE
ANIMALS AND METHODS
• Animals (I, II)
• Methods (I,II)
• PATIENTS AND METHODS
• Paper III
– Patients
– Methods
• Paper IV
– Patients
– Methods
• Paper V
– Patients
– Methods
RESULTS
• Paper I
• Paper II
• Paper III
• Paper IV
• Paper V
GENERAL DISCUSSION
• Corticosteroid effects on the supraspinatus tendon
• Carrageenan-induced subacromial bursitis in rats
• Subacromial distance
• Calcifications in the supraspinatus tendon
• Surgical biopsies of the supraspinatus tendon
CONCLUSIONS
ACKNOWLEDGEMENTS
REFERENCES
Author: Tillander, Bo
Source: Linköping University
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