Radio frequency (RF) lesioning and deep brain stimulation (DBS) are the two prevailing surgical treatments for movement disorders within the field of stereotactic and functional neurosurgery. For RF-lesioning, a small volume of brain tissue is coagulated and knowledge of the lesion size and growth is of great importance for the safety and outcome of the procedure. This thesis deals with adapting the laser Doppler perfusion monitoring (LDPM) technique for measurements in brain tissue during RF-lesioning. The relation between LDPM signal changes and developed lesion size was investigated. LDPM measurements were evaluated both in vitro (albumin protein solution) and in vivo in the porcine brain during RF-lesioning corresponding to a bilateral thalamotomy in man…
Contents
1 Introduction
2 Neurosurgical background
2.1 THE HUMAN BRAIN
2.1.1 The basal ganglia and thalamus
2.1.2 Movement disorders and Parkinson’s disease
2.2 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
2.2.1 Stereotactic frames and targeting principles
2.2.2 Intracerebral guidance
2.2.3 Radio frequency lesioning
2.2.4 Deep brain stimulation
3 Biomedical optics background
3.1 PRINCIPLES OF LASER DOPPLER PERFUSION MONITORING
3.2 PRINCIPLES OF DIFFUSE REFLECTANCE SPECTROSCOPY
4 Aim of the thesis
5 Equipment and validation
5.1 NEUROSURGICAL EQUIPMENT
5.2 RF-ELECTRODES AND MEASUREMENT PROBE
5.2.1 The angular RF-electrode
5.2.2 The optical probe
5.2.3 Electrode evaluation
5.3 LASER DOPPLER PERFUSION MONITORING SYSTEMS
5.3.1 Single and four channel LDPM system
5.3.2 Laser Doppler system validation
5.4 DIFFUSE REFLECTANCE SPECTROSCOPY SYSTEMS
5.4.1 Spectroscopy system evaluation
6 Experimental and surgical studies
6.1 LASER DOPPLER PERFUSION MONITORING DURING RF-LESIONING
6.1.1 Albumin flow model with scatterers, Paper I
6.1.2 RF-lesioning in porcine brain, Paper II
6.1.3 Statistical tests and results, laser Doppler perfusion monitoring studies
6.2 DIFFUSE REFLECTANCE SPECTROSCOPY EXPERIMENTS
6.2.1 Reflectance spectroscopy during RF-lesioning in porcine brain tissue, Paper III
6.2.2 Reflectance spectroscopy in human brain tissue during neurosurgery,
6.2.3 Statistical tests and results, spectroscopy studies
6.3 OPTICAL PROPERTIES ESTIMATED FROM EXTRACTED PORCINE BRAIN TISSUE,PAPER
7 Summary of papers
7.1 PAPER I, RADIO FREQUENCY ELECTRODE SYSTEM FOR OPTICAL LESION SIZE ESTIMATION IN FUNCTIONAL NEUROSURGERY
7.2 PAPER II, OPTICAL MEASUREMENTS DURING EXPERIMENTAL STEREOTACTIC RADIOFREQUENCY LESIONING
7.3 PAPER III, IN VIVO REFLECTION SPECTROSCOPY MEASUREMENTS IN PIG BRAIN DURING STEREOTACTIC SURGERY
7.4 PAPER IV, DIFFUSE REFLECTANCE SPECTROSCOPY MEASUREMENTS FOR TISSUE TYPE DISCRIMINATION DURING DEEP BRAIN STIMULATION
7.5 PAPER V, IN VITRO MEASUREMENTS OF OPTICAL PROPERTIES OF PORCINE BRAIN USING A COMPACT NOVEL DEVICE
8 General discussion and conclusions
9 Acknowledgements
10 Appendix
11 References
Author: Antonsson, Johan
Source: Linköping University
Download URL 2: Visit Now