Diabetic nephropathy (DN) is linked to deaths because of cardiovascular disease and renal failure. This research concentrates on the affect of glycemic control on the development of DN and the metabolic consequences of diabetic nephropathy DN. The euglycemic hyperinsulinemic clamp approach was adopted to evaluate insulin sensitivity and insulin clearance. A couple of different registries, the Diabetes Incidence Study in Sweden (DISS) and the Swedish Childhood Diabetes Registry, in addition to questionnaires and data from medical records had been used to examine diabetic difficulties in population-based cohorts. Microalbuminuria is definitely an early marker of DN and may even also be connected with impaired insulin sensitivity in diabetic and non-diabetic subjects. We researched the link between insulin sensitivity and the level of albuminuria in patients with type 1 diabetes and micro or macroalbuminuria but normal glomerular filtration rate (GFR)…
Contents: Metabolic aspects on diabetic nephropathy
BACKGROUND
Diabetes and its complications
Diabetic nephropathy – a historic perspective
Pathogenesis of diabetic nephropathy
Clinical development and presentation
Metabolic consequences
Hormones and cytokines
Clinical management
Summary
RESEARCH QUESTION AND SPECIFIC AIMS
METHODS
Study cohorts
Renal function
Blood chemistry
Insulin sensitivity in vivo
Insulin sensitivity in vitro
Registers, questionnaires and medical records…
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Source: Umea University
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