The gastric pathogen Helicobacter pylori infects over fifty percent of people throughout the world. H. pylori have the ability to establish persistent infection, which could be life-long if not cured. To be able to set up this kind of infection, this pathogen needs to take care of the host immunity mechanism. H. pylori has specific qualities that make the bacteria significantly less reported to the host immune system. On top of that, for staying in the harsh and acidic environment of the stomach with peristaltic movements and a high frequency of turnover of epithelial cells, H. pylori has evolved various binding modes to structures present both in the mucus and on the surface of gastric cells and also to extracellular matrix proteins. Obviously, adhesion carries a determinant role for a successful colonization by H. pylori. It’s been shown that a small percentage of the H. pylori infection is in intimate contact and connected to the host epithelium. Regardless of its little proportion, this group maintains the persistency of infection…
Contents
Source and Transmission of Heliobacter pylori (H. pylori)
Host responses & disease outcome
Peptic ulcer
Gastric cancer
H. pylori infection parameters
H. pylori colonization factors
Urease
Flagella
H. pylori virulence factors
Vacuolating cytotoxin (VacA)
cag pathogenicity island (cag-PAI)
Adhesion
Adhesins
Blood group Antigen Binding Adhesin (BabA)
Sialic acid Binding Adhesin (SabA)
Adherence-associated LipoProteins (AlpA/AlpB)
H. pylori Adhesin A (HpaA)
Lipopolysaccharide (LPS)
Neutrophil activating protein (HP-Nap)
Aim of the present investigations
Result and discussion
Concluding remarks
Acknowledgments…
Source: Umea University
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