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Although they have improved the health of countless numbers of humans and animals, antibiotics have been losing their effectiveness since the beginning of the antibiotic era. The use of antibiotics in raising food animals has contributed significantly to the global pool of
The Escherichia coli chaperonin GroEL assists in the re-folding of misfolded substrate proteins (SPs). In response to the binding of ATP, GroEL undergoes large, allosteric structural transitions, resulting in an expansion of its central cavity and a capping of the cavity by
Life is a thing taken for granted by most. However, it is the life-long quest of many to unravel the mysteries of it. Understanding and characterizing the incomprehensively complex molecular interaction networks within a biological organism, which defines that organism, is a
The large majority of the currently used drugs are small molecules that interact with proteins. Understanding protein-ligand recognition is thus central to drug discovery and design. This has stimulated the development of chemogenomics and proteochemometrics (PCM) that take target information… Contents 1.
In the first part, the preparation and properties of chalcogen-containing vitamin E analogues are described. The sulfur compound 3,3,4,6,7-pentamethyl-2,3-dihydrobenzo[b]thiophene-5-ol was prepared by two different routes using ionic… Contents 1. INTRODUCTION 1.1 Oxygen in biological and polymeric systems 1.1.1 General introduction 1.1.2 Mechanism
Traffic has been identified as a significant heavy metal polluter of roadside soils, and copper (Cu), lead (Pb) and zinc (Zn) in particular are associated with road travel… Contents 1 INTRODUCTION 1.1 AIM 2 MAURITIUS 3 PREVIOUS STUDIES ON IMPACT FROM ROADS
Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation.The aim of this work was to
The role of infauna on permeable sediment processes is poorly understood due to methodological limitations and a lack of empirical data. The interactions among porewater flows, sediments, and biogenic structures present a physically and … Contents Chapter 1: Executive Summary: Infaunal Effects
This thesis investigates aspects of field theories and soliton solutions with nontrivial topology. In particular we explore the following effective models: a limited sector of the scalar Electroweak theory called extended Abelian Higgs model, and a classical mechanics model derived from the
The red tide organism Chattonella marina (Raphidophyceae) has been associated with fish kills, leading to serious economic losses and posing a significant ecological risk to marine biota. The precise toxic actions of these algae remain unclear, but there is growing scientific evidence