Medical

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Systemic sclerosis: vascular, pulmonary and immunological aspects

In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality.The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor

Midgut and muscle development in Drosophila melanogaster

The fully developed and functional Drosophila midgut comprises two layers, the visceral mesoderm and the endoderm. The visceral muscle of the midgut is formed by the fusion of founder cells with fusion competent cells to form the muscle syncytia. The specification of these cells and thus the fusion and the formation of the midgut muscle is dependent on the Receptor tyrosine kinase (RTK)

Genetic analysis of murine malaria

The project included a genome-wide polymorphism questionnaire using microsatellite markers performed on 10 WDIS. Comparisons of these strains to laboratory inbred strains validated a higher rate of polymorphism among the WDIS. We deduce that these WDIS signify repositories of unique naturally occurring genetic variability that could turn out to be important for the research of complex phenotypes.

Hormone replacement therapy: benefits and adverse effects

Several researches indicate that estrogen replacement therapy (ERT) is an efficient remedy for vasomotor symptoms, insomnia and vaginal dryness. Benefits are also shown on lipid patterns and on the incidence of osteoporotic fractures. As ERT estrogen replacement therapy enhances the risk of endometrial

Physical training in patients with chronic obstructive pulmonary disease – COPD

Chronic obstructive pulmonary disease, COPD, places a substantial burden of disability on the growing number of patients and causes large costs for the society. Tobacco smoke is the most important risk factor. Progressive exertional dyspnea is the major symptom which leads to diminished physical and social activities, reduced physical capacity and decreased health related quality of life, HRQoL.

Postnatal care – outcomes of various care options

Within high-income nations, clinic period of stay after having a normal delivery has steadily decreased correspondingly to period of stay in proper care of other patients. A brief stay gives a greater opportunity for autonomy as well as an increased sense of contribution, however it may involve great problems satisfying parental guidance as well as on the chance of preventing, acquiring, and treating neonatal health conditions.