Biomedicine and Surgery Project Reports, Dissertation, Thesis, Biomedicine Working Papers, Research Papers, Examples, Tips, Resources and Information

Migraine and Pain Insensitivity: Genetics Causes

This project has main purpose to understand the root genetic causes for pain by examining a couple of large families suffering from migraine and pain insensitivity. Pain is a major public health condition around the globe. Enhanced knowledge of the several forms of pain and detection of susceptibility genes can benefit treatments. Migraine is among the most widespread neurovascular disorders, hurting a big part of men and women. Some topics studied in this report are: Genetic epidemiology, Types of migraine, Migraine without aura (MO), Migraine with aura (MA), Familial hemiplegic migraine (FHM), Heritability of migraine, etc.

Plasmin a potent pro-inflammatory factor

Plasmin, the main molecule of the plasminogen activator system, is actually a broad-spectrum serine protease. Plasmin is vital for the degradation of fibrin as well as other elements of the extracellular matrix (ECM) in a variety of physiological and pathological processes. The

Genetic analysis of murine malaria

The project included a genome-wide polymorphism questionnaire using microsatellite markers performed on 10 WDIS. Comparisons of these strains to laboratory inbred strains validated a higher rate of polymorphism among the WDIS. We deduce that these WDIS signify repositories of unique naturally occurring genetic variability that could turn out to be important for the research of complex phenotypes.

Deuterium isotopomers as a tool in environmental research

This thesis describes the development and the use of quantitative deuterium Nuclear Magnetic Resonance spectroscopy (NMR) as a tool in two areas of environmental research: the study of long term climate-plant interactions and the source tracking of persistent organic pollutant.Long-term interactions between

Sorting nexin 9 in clathrin-mediated endocytosis

Clathrin-mediated endocytosis is a process by which cells can internalise diverse molecules such as nutrients, antigens and signalling-surface receptors. The creation of clathrin-coated vesicles demands interplay between the plasma membrane lipids, cargo molecules and the proteins that build up the coat.This thesis

Regulation of UV induced apoptosis in human melanocytes

Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every

Laparoscopy and tumour growth

Laparoscopic technique was quickly adopted in general surgery because of less pain, quicker recovery and shorter hospital stay. In the 1990´s several reports on port site metastases restrained the enthusiasm to use laparoscopic surgery in malignant diseases. The numerous reports on port

Norrbottnian congenital insensitivity to pain

Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor β gene (NGFß). Using a model of recessive inheritance, we identified an 8.3-Mb region on

Bacterial toxins for cancer treatment

Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. Tissue homeostasis in multi‐cellular organisms is maintained through intrinsic

Salivary cortisol and post traumatic stress symptoms : -a ten year follow-up of Swedish UN soldiers after a 6 months mission in Bosnia

Mental effects of severe psychological distress and psychological reactions to combat experiences have been studied in many aspects during the past century. This is to my knowledge the first time a ten-year follow-up study of salivary cortisol concentrations measured by immunoassays in

Biomedicine/Surgery