Adult Coeliac Disease in Clinical Practice

Coeliac disease (CD) is regarded as the consequence of sophisticated interplay of intrinsic (genetic) factors and variable extrinsic (environmental) factors. The complex background of CD clarifies its wide spectrum of clinical manifestations. For a number of years Coeliac Disease CD was considered pretty much a disease of childhood, that was very uncommon in adults. Nowadays we all know that CD is among the most typical food intolerance disorders. An epidemiological study of Coeliac Disease CD in a geographically defined area of Sweden (Paper1) showed a prevalence of 95.5/ 100 000 inhabitants. Among the connected diseases a particularly high incidence of associated thyroid disease, 10.8% was observed.In a fifteen-year cohort follow up study of all Coeliac Disease CD-patients residing in the counties…

Contents: Adult Coeliac Disease in Clinical Practice

Introduction
Historical aspects
Diagnostic criteria
Histopathology
Serology
Pathogenesis
Epidemiology
Associated diseases
Management
Mortality and malignancy
Freedom from symptoms, and a perfect quality of life: the ultimate outcome
Aims of the study
Material and methods
Patients and definition of coeliac disease
Serologic assays
Dietary compliance
Measuring GI symptoms
Results
Paper I
Epidemiology and associated diseases
Paper II
Malignancies and mortality
Paper III
Antibody titres decline quickly after
start of a GFD
Paper IV
Serological correlates to mucosal…

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