Autoimmune mechanisms and genetic susceptibility contribute to the pathogenesis of primary Sjögren’s syndrome and SLE. These chronic systemic autoimmune diseases have many serological and clinical features in common and have an impact on daily life. The studies in this thesis aim to elucidate their autoimmune mechanisms…
Contents
Introduction
Background
Sjögren’s syndrome
History and epidemiology
Clinical features
Diagnosis and classification
Etiology
Alpha-fodrin
Minor salivary gland biopsy
Autoantibodies
Treatment
Systemic lupus erythematosus
History and epidemiology
Clinical features
Diagnosis and classification
Etiology
The immune system
Genetics
Hormonal influence
Quality of life
Treatment
The type I interferon system
General overview
Role in autoimmunity
Present investigation
Aims of the project
Materials and methods
Patients
In vitro transcription and translation assay
Interferon-D immunoassays and induction
Genotyping on microarrays
Health-related quality of life questionnaires…
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Author: Nordmark, Gunnel
Source: Uppsala University Library
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