Severe Traumatic Brain Injury (sTBI) is really a main reason for death. The research in Severe Traumatic Brain Injury (TBI) and aneurysmal Subarachnoid Hemorrhage (SAH) are severe cerebral emergencies. They’re well known factors behind extensive morbidity and mortality in youngsters and adults in the western world. This report is in accordance with 5 clinical research projects in patients with severe TBI (I-IV) and SAH (V), is concentrated on investigation of pathophysiological developments and of evaluation of therapeutic approaches in an effort to improve outcome after cerebral emergency. The treatment for severe TBI patients is an intracranial pressure (ICP)-targeted therapy. This treatment therapy is influenced by physiological principles for cerebral volume regulation, to be able to maintain a normal cerebral microcirculation and a normal ICP. The primary objective is to avoid progression of secondary brain injuries, thereby avoiding brain oedema and worsened microcirculation……
Contents
INTRODUCTION
BACKGROUND
Basic Brain Physiology & Pathophysiology
Endothelium & Blood Brain Barrier
Endothelial dysfunction
Inflammation
Asymmetric Dimethylarginine (ADMA)
Brain Oedema
Severe traumatic brain injury
Primary Brain Injury
Secondary Brain Injury
Management of severe TBI patient
The ICP-targeted therapy
Dihydroergotamine (DHE)
Prostacyclin (epoprostenol)
Vasoactive drugs
Microdialysis
Cerebral glucose, lactate and pyruvate
Subarachnoidal Haemorrhage (SAH)
Scoring / Appendix
AIMS OF THE THESIS
PATIENTS & METHODS
Monitoring
Scoring
Microdialysis
Cytokines
Asymmetric dimethylarginine
C-reactive protein
RESULTS & COMMENTS
Characteristics
Management and treatment results
Physiological parameters
Implementation
Fluid management
Pharmacology treatment
Prostacyclin
Microdialysis
Inflammatory response in severe TBI patients
ADMA and inflammatory response in SAH patients
Organ failure
Outcome
DISCUSSION……………..
Source: Umea University
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Traumatic brain injury (TBI) takes place when an external force traumatically injures the brain. TBI is usually categorized based on severity, mechanism or other features (e.g., occurring inside a particular area or over a widespread area). Head injury typically is the term for TBI, but is actually a broader category simply because it may involve injury to structures apart from the brain, for example the scalp and skull………