Exposure to traffic-derived air pollution is associated to high incidence of respiratory and cardio-vascular morbidity and mortality. Diesel engines and fossil fuel contribute to a great amount to the ambient particulate matter pollution. Exposure to diesel exhaust in healthy volunteers is known to cause inflammatory and oxidative responses in the airways. In contrast, very little is known about the air pollution-related mechanisms behind the adverse cardiovascular effects and why patients with cardiorespiratory disease are more susceptible to the adverse effect of particulate matter air pollution…
Contents
INTRODUCTION
BACKGROUND
Particulate matter air pollution
Epidemiological studies on health effects of PM pollution
Health effects in infants by PM pollution
Impaired lung growth and lung function in children
Asthma
COPD
COPD and occupational exposure
Cardiovascular Disease
EXPERIMENTAL STUDIES OF PM POLLUTION
Diesel exhaust
Controlled exposure to particulate matter air pollution
In-vitro and animal studies
Experimental studies in humans
AIMS
SUBJECTS AND METHODS
STUDY DESIGN
Subjects
Subject Preparation
Chamber exposures
Lung function measurements
Sputum induction and processing
Sputum analyses
Analysis in peripheral blood in study II
Venous occlusion pletysmography studies III-V
Venous occlusion plethysmography
Venous sampling and laboratory assays studies III-V
Data analysis and statistics
MAIN RESULTS
STUDY I
STUDY II
STUDY III
STUDY IV
STUDY V
DISCUSSION
Studies I and II
Diesel exhaust effects in COPD patients
Discussion of Results
Conclusions from diesel exhaust exposures in COPD…..
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Author: Törnqvist, Håkan
Source: Umea University
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